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Dep. of PDN - Sarah Bray's group

From stem cells to tissues: Notch regulatory networks in development

The Notch pathway is one of a small handful of cell signalling pathways that coordinate animal development, regulating the types and numbers of cells formed in many developmental contexts. Its roles include the maintenance of stem cell/progenitor populations, a requirement that continues during tissue homeostasis in the adult. Aberrant Notch function is also implicated in many diseases including dementia and many cancers. Elucidating how Notch signalling functions in different contexts is thus not only vital for understanding development but also has the potential to identify novel markers to aid treatments for human diseases.

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