Our group seeks to elucidate general principles of gene expression and protein complex assembly. We study protein complexes in terms of their 3D structure, structural evolution and the principles underlying protein-complex formation and organisation. We also explore the regulation of gene expression during switches in cell state, and use mouse T-helper cells as a model of cell differentiation. We combine computational and wet-lab approaches at both EMBL-EBI and the Wellcome Trust Sanger Institute.
Interactions between proteins are central to molecular biology, and determine protein structure and function. By analysing the protein complexes of known three-dimensional structure, we discover patterns and principles of protein interactions, their assembly and evolution.
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