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IMAGES

a network for developers and users of imaging and analysis tools

Studying at Cambridge

 

Bio-Imaging

Gopi SHAH: ‘Panoramic Light Sheet Microscopy’

Gopi SHAH: ‘Panoramic Light Sheet Microscopy’

The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging. We developed a 4-lens light sheet microscope combined with real-time image-processing engine that projects the 3D image volume onto a 2D map, reducing the data generated as well as providing a panoramic view of the sample. In my talk, I will discuss our multi-dimensional imaging approach, integrating whole-embryo live imaging, genetic information and analysis of an ensemble of specimen to understand how large-scale tissue movements shape the early zebrafish embryo.

Gopi SHAH: ‘Panoramic Light Sheet Microscopy’ - Read More…

Using microscopy to systematically catalogue gene functions

Using microscopy to systematically catalogue gene functions

Classical genetics has typically focused on dissecting how genes or pathways control a given process within cells. However, many genes likely play roles in multiple processes, which are potentially linked to one another. Unravelling those multiple roles and links is a pressing challenge if we are to understand how healthy cells function normally as integrated systems and, conversely, how complex cellular pathologies arise in disease and how to fix them.

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Find the mitotic index

Find the mitotic index

At the CRUK CI, we use an automated high-content microscope to image thousands of cells and then determine the percentage of mitotic cells with the associated commercial software.

Find the mitotic index - Read More…