The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging. We developed a 4-lens light sheet microscope combined with real-time image-processing engine that projects the 3D image volume onto a 2D map, reducing the data generated as well as providing a panoramic view of the sample. In my talk, I will discuss our multi-dimensional imaging approach, integrating whole-embryo live imaging, genetic information and analysis of an ensemble of specimen to understand how large-scale tissue movements shape the early zebrafish embryo.
Oncogene-Induced Remodelling of Cellular Networks: A Systems Biology Approach Using Optogenetics and Next-Generation Microscopy
Horizon Magazine February 2015. From visualising microscopic cells to massive galaxies, imaging is a core tool for many disciplines, and it’s also the basis of a surge in recent technical developments – some of which are being pioneered in Cambridge. Today, we begin a month-long focus on research that is exploring far beyond what the eye can see, introduced here by Stella Panayotova, Stefanie Reichelt and Carola-Bibiane Schönlieb.
Classical genetics has typically focused on dissecting how genes or pathways control a given process within cells. However, many genes likely play roles in multiple processes, which are potentially linked to one another. Unravelling those multiple roles and links is a pressing challenge if we are to understand how healthy cells function normally as integrated systems and, conversely, how complex cellular pathologies arise in disease and how to fix them.
Do you have a stunning image or video connected with or resulting from your research? Perhaps something created by a new imaging technique, high speed photography or time-lapse camera? It can be anything from the nanoscale to the astronomical.
In October 8th 2014, The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2014 to Eric Betzig, Stefan W. Hell and William E. Moerner "for the development of super-resolved fluorescence microscopy". For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation. Their ground-breaking work has brought optical microscopy into the nanodimension.
The photos "Mathematical analysis can make you fly" and "Rayleigh-Taylor instability" received 1st prizes in the EPSRC science photo competition 2013
A collaborative project between the Institute of Astronomy and the CRUK Cambridge Institute.
TECHNOLOGY STRATEGY BOARD – call for feasibility studies “Seeing more than before – emerging imaging technologies”
GeoS is a desktop application for the assisted delineation of regions within 3D medical scans, such as computed tomography (CT) and magnetic resonance (MR).
With a selection of presentations given from researchers in the arts, astronomy, cancer research, computer science, engineering and mathematics we covered a broad range of topics represented in the IMAGES network. More than 50 people attended and ...
Image segmentation problems appear in areas such as image editing (separating foreground from background, merging multiple images), medical applications (separating gray and white matter, finding structures in medical images), and biological imaging (finding cells and nuclei, detecting cancerous cells).
At the CRUK CI, we use an automated high-content microscope to image thousands of cells and then determine the percentage of mitotic cells with the associated commercial software.